ABSTRACT
Carcinoma cuniculatum (CC), is a rare well-differentiated, low-grade variant of squamous cell carcinoma. However, diagnosis of oral CC has remained very difficult, because many pathologists and clinicians remain un acquainted with oral CC, because there are very few reported cases of this disease in the oral cavity. To our knowledge, no more than 60 head and neck cases have been reported since Flieger and Owinski first described a case involving the mandible in 1977, because there are very few published cases of this disease in the oral cavity, the aim of this report is to provide a detailed clinical and histopathologic description of carcinoma cuniculatum of the maxila, provide a brief review of the literature, and highlight the difficulties in arriving at the correct diagnosis.
ABSTRACT
@#Carcinoma cuniculatum is a rare, slow growing tumour which is commonly mistaken for warts or corn especially when it presents on the sole. Although it rarely metastasizes, it may cause local invasion affecting the underlying tissue and bone. Early identification provides good prognosis as it can be managed with localized resection. We present a case of carcinoma cuniculatum which was misdiagnosed and treated as a common wart for two years until the diagnosis was confirmed by histopathology. By the time of diagnosis, the lesion had involved the underlying bone and patient required amputation. Carcinoma cuniculatum is rare and easily confused with common warts in the early stages hence, it is important to create awareness to identify and differentiate these two conditions.
ABSTRACT
Abstract: Epithelioma cuniculatum is characterized as a slow growing lesion on the sole of the foot. A diagnosis is usually delayed by a low clinical suspicion and misdirection due to its similarity to an infection. This tumor rarely metastasize but a local invasion of adjacent soft tissues is common, requiring ample surgical resection or even amputation in advanced cases. We report a case a 76-year-old patient with a 5-year-old lesion on the sole of the foot, which was originally treated as a wart without improvement while the lesion slowly evolved. The patient was referred to our center with a diagnosis of chronic osteomyelitis. An excisional biopsy revealed an invasive keratinizing squamous carcinoma. In this advanced phase of the disease the only possible treatment was a Syme amputation.
Resumen: El epitelioma cuniculatum se caracteriza por una lesión de crecimiento lento en la planta del pie cuyo diagnóstico suele retrasarse por la baja sospecha clínica y por su similitud con una infección. Este tumor raramente metastatiza, pero es común que produzca una invasión local a los tejidos blandos adyacentes, requiriendo una amplia resección quirúrgica o incluso una amputación en casos avanzados. Presentamos un caso de un paciente de 76 años con una lesión de 5 años de edad en la planta del pie, que originalmente fue tratada como una verruga plantar común sin mejoría, mientras que la lesión evolucionó lentamente. El paciente fue remitido a nuestro centro con un diagnóstico de osteomielitis crónica. Una biopsia excisional reveló un carcinoma escamoso queratinizante invasivo. En esta fase avanzada de la enfermedad el único tratamiento posible fue una amputación de Syme.
ABSTRACT
Introducción: El epitelioma cuniculatum es una variante infrecuente del carcinoma epidermoide, es el subtipo cutáneo del carcinoma verrugoso, que afecta al pie y que puede estar relacionado con el virus papiloma humano (VPH). El hecho de que la lesión inicial sea a menudo confundida con una verruga plantar dilata su diagnóstico y tratamiento. Objetivo: reportar un caso poco frecuente de un paciente con carcinoma cuniculatum del pie derecho, relacionado con VPH, de larga evolución, que se extendió formando una masa vegetante, afectando los tres últimos dedos. Presentación del caso: se presentó un paciente masculino blanco (fototipo III) de 69 años de edad, que en tres ocasiones se le habían resecado verrugas plantares en el pie derecho, presentó una evolución tórpida con aparición de lesión ulcerosa de 2 centímetros de diámetro, con biopsia positiva a carcinoma epidermoide asociado a VPH, al cual se le realizó desarticulación con bordes de seguridad de la lesión. Conclusiones: Se presentó un raro caso de carcinoma epidermoide del pie, relacionado con una verruga plantar asociada a VPH, la cual inicialmente fue extirpada quirúrgicamente de forma inadecuada(AU)
Introduction: Epitelioma cuniculatum is an unusual variant of epidermoid carcinoma. It is the subtype of cutaneous verrucous carcinoma that affects the foot and can be associated with the human papillomavirus (HPV). The lesion is frequently confused with plantar warts, delaying its diagnosis and treatment. Objective: To present an uncommon case of a patient with long history of epitelioma cuniculatum of the right foot associated with HPV, which spread out forming a vegetative mass affecting the last three toes. Case presentation: A sixty-nine-year-old white male patient (phototype III) that in three different moments had undergone excision of plantar warts in the right foot presented a torpid evolution with the appearance of ulcerative lesion of two centimeters in diameter. The biopsy was positive to epidermoid carcinoma associated with HPV; so, resection including safety margins around the tumor was performed. Conclusion: An unusual case of epidermoid carcinoma of the foot related to a plantar wart associated with HPV, which was initially removed by inadequate surgery, is presented(AU)
Subject(s)
Humans , Male , Aged , Warts , Carcinoma, Squamous Cell , Carcinoma, Verrucous , Alphapapillomavirus , Foot/pathology , Biopsy/methodsABSTRACT
Carcinoma cuniculatum (CC) is a rare variant of squamous cell carcinoma (SCC). Only 27 cases have been published in English. A 50-year-old male, who presented a white nodule with erythematous areas, localized in the lateral border of the tongue with 2 months of duration. The patient presents oral lichen planus lesions on the tongue, commissure, and buccal mucosa. The microscopy evaluation of the nodular lesion of the tongue revealed a malignant epithelial neoplasia characterized by cuniculatum architecture, similar in appearance to “rabbit burrows” and the final diagnosis was of CC. The management of CC needs cooperation between surgeons and pathologists to establish a correct diagnosis and treatment. CC is a rare entity and must be recognized by oral pathologist so that it is not misdiagnosed as verrucous carcinoma or oral SCC (OSCC). Regarding prognosis, CC must be evaluated and distinguished from other variants of OSCC.
ABSTRACT
We report on a patient who presented to our clinic with a volume increase and pain at left maxillary region. A biopsy of the area was performed and the lesion was diagnosed as differentiated squamous cell carcinoma of the type cuniculatum. Due to the size of the tumor and compromise of vital intracraneal structures it was decided to perform surgical drainage and later is evaluated because of the tumor persistence to ultimately use palliative care...
Se presenta a una paciente que acudió a nuestra clínica con un aumento de volumen y dolor en región maxilar izquierda. Se realizó una biopsia del área y la lesión fue diagnosticada como carcinoma de células escamosas diferenciado de tipo cuniculatum. Debido al tamaño del tumor y el compromiso de estructuras intracraneales vitales, se decidió realizar un drenaje quirúrgico y posteriormente se evalúa la causa de la persistencia del tumor para finalmente entregar cuidados paliativos...